The connection between genomic variability and the expression of a phenotype is often complex. Furthermore, in genetics, we often think about DNA sequences and RNA expression levels. However, many complex as well as Mendelian diseases are caused by the accumulation of misfolded proteins, and a clear correlation between DNA, RNA, and protein folding is sometimes missing. Learn more at: http://www.illumina.com/applications/sequencing/dna_sequencing.html Products: TruSeq® sample preparation kit: http://www.illumina.com/products/truseq_rna_library_prep_kit_v2.html Illumina HiSeq®: http://www.illumina.com/systems/hiseq_2500_1500.html Publication Links: PMID: 26998692| Dooley, et al. (2016): http://www.ncbi.nlm.nih.gov/pubmed/ 26998692 PMID: 27065010| Chen, et al. (2016): http://www.ncbi.nlm.nih.gov/pubmed/ 27065010 The Science Mondays (SciMon) series is brought to you by Illumina http://www.illumina.com/ Illumina hosts -- Irene Predazzi, Sr Scientific Liaison, Scientific Affairs and Jacques Retief, Associate Director Scientific Affairs -- give you a quick report on breaking news. A global genomics leader, Illumina provides comprehensive next-generation sequencing solutions to the research, clinical, and applied markets. Illumina technology is responsible for generating more than 90% of the world’s sequencing data.* Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond. *Data calculations on file. Illumina, Inc., 2015. Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc View customer spotlight videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79 View Illumina webinars https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ View Illumina product videos https://www.youtube.com/playlist?list=PLKRu7cmBQlaj6YuZmkfxZcT9twqDgP2Xd View Illumina support videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWb-JOnusJfYvM